New Step by Step Map For ceesdekker
New Step by Step Map For ceesdekker
Blog Article
Using one-molecule optical and AFM imaging and pressure-spectroscopy strategies, we look for to unravel the mechanistic components of the framework and dynamics of chromosomes. Our investigation interests include:
1996, very first mesoscopic cost density waves equipment; and very first electrical measurements on one metallic nanocluster among nanoelectrodes
Multicolor imaging from the bacterial nucleoid and mobile division proteins with blue, orange, and in close proximity to-infrared fluorescent proteins
Our do the job was immediately adopted up by others, most notably by Phaedon Avouris and colleagues at IBM, who in October 1998 printed their findings on transistors produced from single- and multi-walled carbon nanotubes in Applied Physics Letters.
2012, discovery that nucleoid occlusion underlies the precision of bacterial cell division; and first at any time study with the dynamics DNA supercoils and the discovery of supercoil hopping
Microbiology has only existed for your century, considering the fact that we started to study micro-organisms much more critically. I believed nanobiology was an ideal time period, for the reason that all molecular Organic applicable interactions occur within the nanoscale: a protein is a handful of nanometres in sizing, DNA is two nm thick.’
‘Initially we looked at Organic systems using a Bodily perspective and acted on the basis in the instruments we realized. It took a several years right before we began Doing work extra on the big biological concerns. I then started to simply call it nanobiology, a time period that didn't exist at the time.
Finding out DNA loop extrusion by SMC proteins for chromosome architecture with single-molecule assays.
The rotors harness energy from the nanoscale drinking water and ion movement that is definitely created by a static chemical or electrochemical potential gradient within the nanopore, which are proven through a salt gradient or used voltage, respectively. These artificial nanoengines self-Manage and run autonomously in physiological circumstances, suggesting tips on how to setting up Electrical power-transducing motors at nanoscale interfaces.
Quite cool, but that wasn’t actually where my curiosity lay. I planned to pioneer and I had the feeling which was now not feasible, since the most appealing fundamental insights had previously been uncovered. But my industry had created a lot of remarkable new resources to measure specific molecules. I made a decision which i wanted to apply this to biology, to take a look at it from a ceesdekker Bodily viewpoint.’
FtsZ treadmilling is essential for Z-ring condensation and septal constriction initiation in bacterial mobile division
2006, to start with demonstration of molecular sorting inside a lab over a chip working with biomotors; discovery of nanobubbles in solid-condition nanopores; and 1st estimate of electrokinetic Electrical power conversion inside a nanofluidic channel
2005, discovery on the system of DNA uncoiling by topoisomerase enzymes; discovery of lengthy-array conformational modifications in Mre11/DNA repair service complexes; and very first drive measurements on a DNA molecule in the nanopore
Last but not least, I'll briefly sketch a number of our Strategies to take a look at the setting up of artificial cells, precisely our first measures to ascertain synthetic cell division.